The working hypothesis was that some people searching for information on heroin and other opioids might overdose in the near future. To test this, a researcher at the University of California Institute for Prediction Technology (UCIPT) and his colleagues developed several statistical models to forecast overdoses based on opioid-related keywords, metropolitan income inequality and total number of emergency room visits. They discovered regional differences (graphic) in where and how people searched for such information and found that more overdoses were associated with a greater number of searches per keyword. The best-fitting model, the researchers say, explained about 72 percent of the relation between the most popular search terms and heroin-related E.R. visits. The authors say their study, published in the September issue of Drug and Alcohol Dependence, is the first report of using Google searches in this way.
To develop their models, the researchers obtained search data for 12 prescription and nonprescription opioids between 2005 and 2011 in nine U.S. metropolitan areas. They compared these with Substance Abuse and Mental Health Services Administration records of heroin-related E.R. admissions during the same period. The models can be modified to predict overdoses of other opioids or narrow searches to specific zip codes, says lead study author Sean D. Young, a behavioral psychologist and UCIPT executive director. That could provide early warnings of overdose clusters and help to decide where to distribute the overdose reversal medication Naloxone.
Still, this approach has limitations. Not everyone uses Google, and some search terms lacked important context: “brown sugar” (slang for a type of heroin) was the most popular one for opioids in the majority of cities studied, but the researchers noted that their model could not distinguish it from the baking ingredient. In addition, the overdose data in the study were relatively old.
Jeanine Buchanich, a biostatistician at the University of Pittsburgh, who was not involved in the prediction study, says that “the paper highlights the need for new, innovative approaches to analyzing data related to the opioid epidemic.”